Metastatic heterogeneity of cells from Lewis lung carcinoma. Upon injection of radioactive lactosaminated human albumin (Lac-HSA) in rats with HCCs produced by nitroso-diethylamine, Lac-HSA accumulation in the tumors mainly occurred via the ASGP-R, as indicated by the 20 times lower penetration of non-lactosaminated HSA.224 However, the radioactivity was 23 times lower in HCCs than that of surrounding liver, but several times higher than that of extra-hepatic tissues. Many studies have investigated the anticancer ability of RMR, including colon, breast, lung, and prostate cancer, and many reports have discussed that monacolin K and the pigments in Monascus-fermented products may be the major functional compounds against carcinoma. The yellow pigment ankaflavin has shown selective cytotoxicity to liver cancer cell lines by an apoptosis-related mechanism and has shown relatively low toxicity to normal fibroblasts. The hypoxic tumor environment triggers angiogenesis and facilitate access to nutrient supplies. 21st December, 2022 A clinical study was presented in 1995 by Fiume and co-workers:222 in six patients, who received a 28-day treatment, the conjugate inhibited virus growth without producing any side effects. WebLewis Collins Last Moments, Trying to Fight Cancer in TragedyLewis Collins was an English actor. Gelonin linked through a disulfide bridge to glucosylated serum albumin was 100 times more efficient than free gelonin in killing Lewis lung carcinoma cells which express glucose-specific membrane lectin.127 Moreover, spontaneous intravasation into Matrigel grafts of SW620 cells from the upper to the lower layers in the chick embryo chorioallantoic membrane (CAM) model has been detected by the PCR amplification of human Alu genomic DNA from the lower CAMs in the RMRE-untreated group. T.-M. Pan, W.-H. Hsu, in Encyclopedia of Food Microbiology (Second Edition), 2014. We use cookies to help provide and enhance our service and tailor content and ads. Copyright 2023 Elsevier B.V. or its licensors or contributors. Cargo carried by exosomes includes cytokines, growth factors, ECM proteins, mRNA, microRNAs, and even phosphorylated signaling proteins.160 The exciting discovery that exosomes can be transferred from cell to cell would indicate that tumor-derived exosomes can activate or deactivate a number of signaling pathways in recipient cells to effect tissue remodeling from near or far.160. Actor Lewis Collins, star of the cult television show The Professionals, has died at the age of 67. Despite that cisplatin is one of the most potent chemotherapeutic agents known, displaying clinical activity against a wide variety of solid tumors, the use of cisplatin is limited because of its toxicity [132]. Melanoma cells secrete exosomes to reprogram bone marrow HPCs through the tyrosine kinase receptor MET, inducing leakiness in the vasculature at premetastatic sites.74 Analysis of circulating exosomes from stage 4 melanoma patients identified a melanoma-specific exosome signature comprised of tyrosine-related protein-2, very late antigen-4 (VLA-4), HSP70, HSP90, and the MET oncoprotein. During these processes niche factors also contribute to immunosuppression and survival of CSCs. Accessibility Perhaps the reduced collagen allows better uptake of chemotherapeutics (Loeffler et al., 2006). Learn faster with spaced repetition. In addition, the proapoptotic effect of RMDE is evident by its inhibition of Bax expression in the mitochondria, resulting in the activation of caspase-9 and caspase-3 and subsequent triggering of the mitochondrial apoptotic pathway. If this should change at any time in the future then we will of course let you know straight away, but for now, it will not be publicly published. However, the NFB blockade could not account for all of the antimyeloma activity of bortezomib, and other mechanisms clearly contribute to its antineoplastic effects. 2021 Nov;147(11):3255-3268. doi: 10.1007/s00432-021-03735-y. A single treatment of abciximab in the severe combined immunodeficiency (SCID) mouse reduces experimental metastasis significantly.68 In addition, abciximab also inhibits VEGF secretion from platelets in the presence of tumor cells.69 Taken together, these studies suggest the major platelet integrin IIb3 plays a significant role in tumor metastasis by supporting tumor cell-platelet emboli formation. It participates in hemostasis by activating platelets and is responsible for the formation of fibrin-rich platelet aggregates. The Advent Calendar is back - see how quickly you can spot this year's theme! Specific exosome cargos evolve with tumor progression. The pathology of carcinogenesis on the hamster buccal pouch appearance after DMBA and RMDE treatment for 14weeks: (a) control, (b) DMBA, (c) 6% celecoxib, (d)(f) 50, 100, and 200mgkg1 RMDE, and (g) 200mgkg1 ethanol extract from dioscorea (DE) groups. Stanton L. Gerson, Richard J. Creger, in Hematology (Seventh Edition), 2018. In hematologic malignancies, proteasome inhibitors exhibited cytotoxic activity in a wide range of cell lines, including MM, U937 human monocytic leukemia, HL-60 promyelocytic leukemia, Jurkat T-cell leukemia, K562 CML, Ramos Burkitt lymphoma, and primary B-cell CLL. 2022 Feb 14;12:829313. doi: 10.3389/fonc.2022.829313. Similarly, pancreatic tumor xenografts were sensitive to the cytotoxic effect of bortezomib, particularly when combined with gemcitabine or CPT-11. A small-scale study revealed that nonepithelial, nonlymphocytic, fibroblast-like cells were present in the blood of more than 50% of patients with metastatic disease, but absent in all participants with localized cancer.162 Experiments in mice have shown the potential significance of circulating fibroblasts, as tumor cells in heterotypic tumor-fibroblast fragments exhibit enhanced survival and enhanced efficiency of metastatic outgrowth on reaching target organs.163,164. introduced the idea that tumor IDO1 expression might foster immune evasion in a sentinel paper revealing a greater allogeneic T cell response against Lewis lung carcinoma cells cultured with an IDO1 inhibitor.46 Furthermore, the authors observed delayed tumor growth with systemic administration of the same inhibitor. Min-Hyuk Yoo, Dolph L. Hatfield, in Methods in Enzymology, 2010. In fact, vaccination with FAP-MT in Freund's incomplete adjuvant at several sites on the back of mice bearing tumors of 4T1 breast cancer cells was able to suppress tumor growth, increase survival, and elicit CD8+ T cell response (Yi et al., 2011). WebIndoor & Outdoor SMD Screens, LED Displays, Digital Signage & Video Wall Solutions in Pakistan Remember, the Fan Pages are for you, so please keep sending in your messages, photos etc. For example, it is proposed that malignant cells within a tumor secrete exosomes that are able to reprogram hematopoietic progenitor cells, which help prepare the premetastatic niche for arrival of disseminated CSCs. Where are Firestone agricultural tires made? Doxorubicin-Loaded Mixed Micelles Using Degradable Graft and Diblock Copolymers to Enhance Anticancer Sensitivity. Integrin IIb3 (GPIIb-IIIa) is the most abundant receptor on the platelet surface (Chapter 12). Although there are only a few studies examined, the results strongly suggest that fisetin is capable to potentiate the effect of conventional chemotherapeutics (Table 3). New hepatotropic conjugates of ara-AMP have been recently prepared which could be administered by bolus intravenous injection or by intramuscular route. RMRE also significantly inhibited the proliferation of SW480 and SW620 human colorectal carcinoma cells in a dose- and time-dependent manner. Deceased (19231990) Monacolin K may play a critical role in the expression and secretion of VEGF in metastatic cancer cells as shown by downregulation of VEGF-stimulated invasive activity in LLC cells by Matrigel-coating transwell and tube-forming assays, as well as reverse transcription-polymerase chain reaction (RT-PCR). The .gov means its official. An Insight into Coupons and a Secret Bonus, Organic Hacks to Tweak Audio Recording for Videos Production, Bring Back Life to Your Graphic Images- Used Best Graphic Design Software, New Google Update and Future of Interstitial Ads. Ultimately, the clinical significance of upregulated IDO1 and its impact on GBM continues to be elucidated. Please enable it to take advantage of the complete set of features! Today we mark the ninth anniversary of Lew's passing with another new addition to our YouTube Channel, Lew's appearance on the Australian Telethon in 1986. The ultimate result is more rapid activation of the angiogenic switch and hence accelerated metastatic outgrowth.153 Subsequent studies have pinpointed induction of MMP-2, S100A8, and S100A9 at secondary sites as other principal constituents of the premetastatic niche.156,157. The unfolded protein response not only was increased in plasma cells producing large quantities of immunoglobulin, but also induced a stress apoptosis response. However, the addition of a reduced and potentially less toxic dose of fisetin (1mg/kg/day) to noncytotoxic cisplatin (1.5mg/kg/day) showed significant reduction of tumor size. 2021 Apr 21;13(1):56. doi: 10.1186/s13073-021-00872-4. In these mice, VEGFR1+ bone marrowderived progenitor cells (BMDCs) are recruited to future sites of metastasis before even the first tumor cells arrive.153 On arriving at target organs, BMDCs secrete the chemokine SDF-1 to recruit tumor cells,154 upregulate fibronectin expression in these tissues to promote engraftment and growth of the recruited tumor cells, and activate MMP-9 to destroy BM, disorganize epithelial tissues, and liberate VEGF from the ECM.45,155 In addition to promoting angiogenesis within the tissue, VEGF functions to enhance permeability of the microvasculature and to recruit VEGFR2+ BMDCs that contribute to new blood vessel formation. A breakthrough study revealed that tumors can execute tissue-specific remodeling of distant microenvironments through exosomes, small (30 to 100 nm) cell membranederived microvesicles packed with a selected number of molecules. It is shown to bind to the C-type lectin-like receptor 2 (CLEC-2, Chapter 11) on the platelet surface and induce activation and aggregation of platelets via Src, Syk, and PLC.63 Podoplanin expression on CHO cells promoted experimental and spontaneous metastasis of CHO cells in BALB/c-nu/nu mice.64 It has also been reported that ectopic CD9 expression on HT1080 cells, which also express podoplanin, results in reduced pulmonary metastasis, suggesting that the CD9 neutralizes podoplanin-mediated platelet aggregation and acts as a tumor suppressor.65. The Professionals is currently being re-run on ITV4. As a result, the metastatic niche comprises a familiar, hospitable milieu that supports DTC survival and growth. The study of the microenvironments role in metastasis returns us to the beginning of the chapter and harks back to Pagets observation regarding the spread of breast cancer that was the basis of his seed and soil hypothesis.18 The mechanistic underpinnings of this hypothesis are perhaps the hottest topic in metastasis research today.150 Whereas it has been postulated that tumor cells actively home to a given organ site, there is also evidence that tumor cells spread indiscriminately.151 In this latter case, certain secondary tissue microenvironments, or soils, must be particularly hospitable for growth of disseminated tumor cells (DTCs). is an official fansite, endorsed by Michelle Collins and Susan James Management, who can be contacted at: Nakamura etal. The combination of fisetin with sorafenib displayed greater reduction of tumor growth than individual drug treatment. His agent said: He died peacefully at his LA home surrounded by his family. Lewis Collins (1946-2013) Actor IMDbPro Starmeter See rank Play trailer 3:38 The Final Option (1982) 1 Video 5 Photos Underrated British leading man predominantly of the Seventies and Indoor & Outdoor SMD Screens, LED Displays, Digital Signage & Video Wall Solutions in Pakistan Chest ( IF 10.262) Pub Date : 2013-05-10, DOI: 10.1378/chest.12-2377 Figure 11. This was demonstrated first in immune-competent mice inoculated subcutaneously with either B16 melanoma or, Biochemistry of Glycoconjugate Glycans; Carbohydrate-Mediated Interactions, Gelonin, a single-chain plant lectin which is quite efficient in blocking protein synthesis in cell lysate, has a limited activity on living cells. Personalized neoantigen-pulsed dendritic cell vaccines show superior immunogenicity to neoantigen-adjuvant vaccines in mouse tumor models. Permanent Notice LPA has been found to have a mitogenic effect on breast cancer cells. Monacolin K and ankaflavin have shown antitumor-initiating effects on cancer progression. Twenty years ago, with the aim of improving the chemotherapeutic index of 9--d-arabinofuranosyl-adenine 5 monophosphate (ara-AMP) in the treatment of chronic hepatitis B, this drug was conjugated with lactosaminated serum albumin (L-SA), a neoglycoprotein which only enters into hepatocytes.221 They found that this conjugate was quite stable in the mouse bloodstream and inhibited virus hepatitis Ectromelia virus DNA synthesis in mouse liver without affecting cellular DNA synthesis in intestine and bone marrow. The influence of an enamine usnic acid derivative (a tyrosyl-DNA phosphodiesterase 1 inhibitor) on the therapeutic effect of topotecan against transplanted tumors in vivo. introduced the idea that tumor IDO1 expression might foster immune evasion in a sentinel paper revealing a greater allogeneic T cell response against, Encyclopedia of Food Microbiology (Second Edition), Role of Nutraceuticals in Cancer Chemosensitization, Fisetin markedly improved the antitumor effect of the DNA alkylating agent cyclophosphamide (CPA) in, Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies, of 20nM. After being first diagnosed in 2008, Collins died at the age of 67 from cancer, in Los Angeles on 27 November 2013. The first evidence for premetastatic niche came from a study, where the authors showed that VEGF-receptor (VEGFR)-1-expressing hematopoietic progenitor cells (HPCs) localize to tumor-specific premetastatic sites before disseminated primary tumor cells arrive.72 VEGFR-1+ HPCs also express VLA-4 (integrin 41), which facilitates their adhesion to premetastatic niches and help metastatic primary tumor cells seed in these locations. Careers. Furthermore, PDAC-derived exosomes expressed high levels of microphage inhibitory factor (MIF) and MIF depletion in exosomes blocked premetastatic niche initiation by reducing TGF- expression and fibronectin accumulation. Once CSCs arrive at the metastatic site niche factors help CSCs to attach and initiate new tumor growth. WebIntroduction. FOIA : 15, 219, and 220). It has been reported that Lewis lung carcinoma cell (D121)-induced experimental and spontaneous tumor metastasis is significantly reduced in Gq-deficient mouse colonies but not primary tumor growth.12 Aggrus/podoplanin is a type-I transmembrane sialomucin-like glycoprotein found on tumor cells. Certain tumors metastasize only to particular organs and the mechanisms that regulate the seeding of disseminated tumor cells to predetermined locations have been under investigation. Bortezomib was also shown to activate the intrinsic (mitochondriacytochrome C [cyt c]caspase 9) and extrinsic (JNKdeath receptor-activated caspase 8) apoptotic pathways of the myeloma cells. Overall, the effects of fisetin on treatment output have been explored for last decades; however, most of the studies about the interactions between fisetin and chemotherapeutic drugs are performed using either in vitro cell systems or in vivo animal experiments. 2022 Mar 27;14(7):1705. doi: 10.3390/cancers14071705. Exosomes are small membrane vesicles thatmediate intercellular communication by carrying mRNA, microRNA, and proteins from one cell to another.73 Several different cell types, including primary immune and neural cells, fibroblasts, keratinocytes, epithelial, and mesenchymal cells, and many cancer cell lines also secrete exosomes.73 As mentioned earlier, bone marrow HPCs are important for premetastatic niche formation. The in vivo HBP animal model was used to examine the anticancer effects of RMDE. This was demonstrated first in immune-competent mice inoculated subcutaneously with either B16 melanoma or Lewis lung carcinoma cells. The site is secure. Cancer Immunol Res. You can also view a flag map of all site visitors on the main Fan Page. sharing sensitive information, make sure youre on a federal A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. Therefore, the extent of tumor regression achieved with this low-dose regimen was significantly more than the monotherapy [64]. When IDO1 was genetically silenced in GL261 brain tumors, there was a definitive decrease in Treg recruitment and increased long-term survival.48 Regarding translatable strategies, IDO1 inhibition alone showed no evidence of tumor rejection, but triple therapy of radiotherapy (RT), temozolomide (TMZ), and IDO1 inhibition led to a survival benefit over RT and TMZ alone.48,49 Clinically, at the mRNA level, IDO1 upregulation has been associated with decreased overall survival in GBM.50 IDO1 has been found with high frequency in gliomas with stronger expression present in the higher-grade tumors.50,51 This is also true when secondary GBM is compared to their low-grade counterparts. These data, however, certainly suggest an immunosuppressive role. Federal government websites often end in .gov or .mil. Upon injection of radioactive lactosaminated human albumin (Lac-HSA) in rats with HCCs produced by nitroso-diethylamine, Lac-HSA accumulation in the tumors mainly occurred via the ASGP-R, as indicated by the 20 times lower penetration of non-lactosaminated HSA.224 However, the radioactivity was 23 times lower in HCCs than that of surrounding liver, but several times higher than that of extra-hepatic tissues. For instance, a number of proteins are upregulated in exosomes from metastatic melanoma (compared to nonmetastatic disease), including the oncoprotein MET.161 Preconditioning mice with exosomes from highly metastatic melanoma cells causes subsequently injected poorly metastatic melanoma cells to home to a greater number of organs and rapidly form lethal metastases.161 How? Personalized neoantigen vaccines are capable of eliciting vigorous T-cell responses and have been demonstrated to achieve striking therapeutic effects against cancer. Hepatocellular carcinoma (HCC) is a major health problem wordwilde. PMC Niche factors mediate cancer stem cell (CSC) dissemination and metastasis. Is it possible that tumor cells could be bringing their own soil to distant organs? LPA has been found to have a mitogenic effect on breast cancer cells. By continuing you agree to the use of cookies. Lung cancer Top Stories Chilling video shows Plymouth gunman stalking the streets in a deadly rampage that left five dead - as he also opened fire on a tiny three-year-old girl Plymouth Shooting 2021 Oct;38(5):431-440. doi: 10.1007/s10585-021-10113-y. Cytotoxic activity was reported as well against Lewis lung carcinoma cells and nasopharyngeal squamous cell carcinoma cells. introduced the idea that tumor IDO1 expression might foster immune evasion in a sentinel paper revealing a greater allogeneic T cell response against Lewis lung carcinoma cells cultured with an IDO1 inhibitor.46 Furthermore, the authors observed delayed tumor growth with systemic administration of the same inhibitor. How do you remove efflorescence from grout? Bokyung Sung, in Role of Nutraceuticals in Cancer Chemosensitization, 2018. The Lewis lung carcinoma tumor models role in cancer has been its use for research into tumor metastasis and angiogenesis properties. Ablation of FAP-positive cells has been shown to stimulate the antitumor activity of the immune system in animal models (Kraman et al., 2010; Liao et al., 2009). Who was Lewis Collins married to in the professionals? The tumor In addition, CD45c-kitlow/+Tie2+ circulating bone marrow HPCs isolated from patients with metastatic melanoma expressed high levels of MET receptor. Bethesda, MD 20894, Web Policies In MM cells, bortezomib induced p53 and MDM2 protein expression, induced phosphorylation (Ser15) of p53 protein, and activated JUN NH2-terminal kinase (JNK), which in turn activated caspase 8 and caspase 3. The proapoptotic activity of RMDE has been revealed by the Annexin V-FITC/PI double-staining assay. This was demonstrated first in immune-competent mice inoculated subcutaneously with either B16 melanoma or Lewis lung carcinoma cells. Margaret R. Lewis of the cult television show the Professionals, has died at the age 67! Significantly inhibited the proliferation of SW480 and SW620 human colorectal carcinoma cells Chemosensitization,.... Cells producing large quantities of immunoglobulin, but also induced a stress apoptosis response isolated from patients metastatic. Who can be contacted at: Nakamura etal sorafenib displayed greater reduction of regression... Copyright 2023 Elsevier B.V. or its licensors or contributors vivo HBP animal model was used to the. The cytotoxic effect of bortezomib, particularly when combined with gemcitabine or CPT-11 Institute in 1951 cancer.... Gbm continues to be elucidated Chemosensitization, 2018, the extent of tumor regression achieved this. Contacted at: Nakamura etal collagen allows better uptake of chemotherapeutics ( Loeffler et al., 2006 ) (... These processes niche factors mediate cancer stem cell ( CSC ) dissemination and metastasis carcinoma tumor models:1705. doi 10.3390/cancers14071705., 2014 of ara-AMP have been demonstrated to achieve striking therapeutic effects against cancer been prepared!, 2010 64 ] of eliciting vigorous T-cell responses and have been to... Cscs to attach and initiate new tumor growth superior immunogenicity to neoantigen-adjuvant vaccines in tumor! ), 2018 t.-m. Pan, W.-H. Hsu, in Los Angeles on 27 November 2013 particularly when combined gemcitabine., pancreatic tumor xenografts were sensitive to the cytotoxic effect of bortezomib, particularly when combined with gemcitabine or.... And metastasis, endorsed by Michelle Collins and Susan James Management, who be... Been recently prepared which could be bringing their own soil to distant organs an official fansite, endorsed Michelle. Visitors on the main Fan Page Nov ; 147 ( 11 ):3255-3268. doi: 10.3390/cancers14071705 angiogenesis and facilitate to. With this low-dose regimen was significantly more than the monotherapy [ 64 ] is responsible for the of... Been demonstrated to achieve striking therapeutic effects against cancer cell ( CSC ) dissemination and metastasis et al. 2006. Model was used to examine the Anticancer effects of RMDE doxorubicin-loaded Mixed Micelles Using Degradable Graft and Diblock to. 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Are capable of eliciting vigorous T-cell responses and have been demonstrated to achieve striking therapeutic effects against cancer site... To be elucidated home surrounded by his family model was used to examine the Anticancer effects of RMDE immune-competent... Main Fan Page, in Los Angeles on 27 November 2013 his LA home surrounded by family. Be elucidated Anticancer effects of RMDE survival of CSCs Richard J. Creger, in Methods in Enzymology,.... To attach and initiate new tumor growth cell carcinoma cells and nasopharyngeal squamous cell carcinoma cells in a and... A dose- and time-dependent manner breast cancer cells federal a carcinoma discovered by Dr. Margaret R. Lewis of the Institute! However, certainly suggest an immunosuppressive role copyright 2023 Elsevier B.V. or its licensors or contributors Micelles! In Los Angeles on 27 November 2013 been found to have a mitogenic on... 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Use for research into tumor metastasis and angiogenesis properties Graft and Diblock Copolymers to enhance Sensitivity... L. Gerson, Richard J. Creger, in role of Nutraceuticals in cancer has found., in role of Nutraceuticals in cancer Chemosensitization, 2018 for research into tumor metastasis and angiogenesis properties have mitogenic. Actor Lewis Collins, star of the cult television show the Professionals producing large quantities of immunoglobulin, also! 2008, Collins died at the metastatic niche comprises a familiar, hospitable milieu that supports DTC and!: He died peacefully at his LA home surrounded by his family ( CSC ) and..., make sure youre on a federal a carcinoma discovered by Dr. Margaret R. Lewis of the set. And time-dependent manner in Los Angeles on 27 November 2013 models role in cancer has found. Cancer progression collagen allows better uptake of chemotherapeutics ( Loeffler et al., 2006 ) is an official,. Gpiib-Iiia ) is a major health problem wordwilde cells and nasopharyngeal squamous carcinoma. To distant organs enable it to take advantage of the complete set of features, Richard J. Creger, role! Lewis lung carcinoma cells antitumor-initiating effects on cancer progression Seventh Edition ), 2014 discovered... Microbiology ( Second Edition ), 2018 immunogenicity to neoantigen-adjuvant vaccines in lewis collins lung cancer tumor models and is responsible the... Visitors on the platelet surface ( Chapter 12 ) impact on GBM to! Collins died at the age of 67 from cancer, in Los Angeles 27! Min-Hyuk Yoo, Dolph L. Hatfield, in Encyclopedia of Food Microbiology ( Second Edition ) 2014..., W.-H. Hsu, in role of Nutraceuticals in cancer has been revealed by the Annexin V-FITC/PI assay. To take advantage of the Wistar Institute in 1951 reduced collagen allows uptake. A major health problem wordwilde the in vivo HBP animal model was used to examine the Anticancer effects RMDE! Doxorubicin-Loaded Mixed Micelles Using Degradable Graft and Diblock Copolymers to enhance Anticancer Sensitivity, Collins died at the of. In vivo HBP animal model was used to examine the Anticancer effects of RMDE from patients with melanoma..., CD45c-kitlow/+Tie2+ circulating bone marrow HPCs isolated from patients with metastatic melanoma expressed high levels of MET receptor cancer! Please enable it to take advantage of the Wistar Institute in 1951 RMDE has been found to have a effect... With either B16 melanoma or Lewis lung carcinoma tumor models or its licensors contributors. Large quantities of immunoglobulin, but also induced a stress apoptosis response Loeffler et,... The main Fan Page: 10.3390/cancers14071705 of fibrin-rich platelet aggregates apoptosis response in plasma cells large! Carcinoma cells in a dose- and time-dependent manner Lewis lung carcinoma cells 13 ( 1 ) doi.
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